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5 MTHF
Thorne Research


5-MTHF (Folate 1 mg (1 000 mcg) the most biologically active form of folate* a breakthrough in folate supplementation the most bioavailable, active form of folate* an excellent source of folate for pregnant women and supports optimal cardiovascular and nerve function* Folic acid must be converted to its active forms to be used by the body.* This is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not occur sufficiently enough to meet the body's needs. Furthermore, up to 60-percent of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF. Because deficiencies of folic acid have been linked to low-birth-weight infants and neural tube defects, folic acid requirements double during pregnancy.* The Centers for Disease Control and Prevention recommends folic acid supplementation for all women of childbearing age because the biggest need is during the first trimester, when a woman may not even be aware she is pregnant. In concert with vitamin B12, 5-MTHF functions as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine.* Methyl-group donation is vital to many biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.* It is important for women of childbearing age to get enough folic acid not just those who are planning to become pregnant. Only 50 percent of pregnancies are planned, so any woman who could become pregnant should get enough folic acid every day especially before conception and during early pregnancy. Folic acid is needed for the formation of red blood cells, and for the prevention of folic acid anemia. This nutrient may help treat depression and anxiety as well as cervical dysplasia and prevent nutritional deficiencies from ongoing birth control use. Folate can be combined with a Vitamin B complex for added support.
  • Common Name: 5 MTHF
  • Ingredients: One Vegetarian Capsule Contains: Folate (as L-5-Methyltetrahydrofolate*) 1 mg. Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide. *This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S). Extrafolate-S is a registered trademark of Gnosis S.p.A. Suggested Use: Take 1 capsule one to three times daily or as recommended by a health-care practitioner.
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